Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches
By R. Sartor, Gary D. Wu. Gastroenterology, 2016
734 citations recorded by the source corpus.
Intestinal microbiota are involved in the pathogenesis of Crohn’s disease, ulcerative colitis, and pouchitis. We review the mechanisms by which these gut bacteria, fungi, and viruses mediate mucosal homeostasis, via their composite genes (metagenome) and metabolic products (metabolome). We explain how alterations to their profiles and functions under conditions of dysbiosis contribute to inflammation and effector immune responses that mediate inflammatory bowel diseases (IBD) in humans and enterocolitis in mice. It could be possible to engineer the intestinal environment by modifying the microbiota community structure or function to treat patients with IBD— either with individual agents, via dietary management, or as adjuncts to immunosuppressive drugs. We summarize the latest information on therapeutic use of fecal microbial transplantation and propose improved strategies to selectively normalize the dysbiotic microbiome in personalized approaches to treatment.
Subfields: Infectious Diseases, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/7393ece531b37af25454661d3ec581a8e557982f
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Citations in the corpus
- The microbiome of pest insects: it is not just bacteria (2019, background): “Other examples of important bacteria–fungi interactions exist in the human (Nguyen et al., 2015; Sartor & Wu, 2017) and in plant microbiome (Vandenkoornhuyse et al., 2015; Toju et al., 2018).”