Comparative genomics of the neglected human malaria parasite Plasmodium vivax

By J. Carlton, J. Adams, Joana C. Silva, Shelby L. Bidwell, H. Lorenzi, E. Caler, J. Crabtree, Samuel V. Angiuoli, E. Merino, P. Amedeo and 30 more. Nature, 2008

820 citations recorded by the source corpus.

The human malaria parasite Plasmodium vivax is responsible for 25–40% of the ∼515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.

Subfields: Parasitology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/1abc46e14c5bdb5323c46512f3696dd2263822ed

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Citations in the corpus

Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax (2011, background): “vivax has an ortholog of Pfs230 (Pvs230) [37].”
Determinants of relapse periodicity in Plasmodium vivax malaria (2011, background): “vivax to be sequenced fully was a long-latency phenotype from El Salvador-Sal 1) [95,96].”
Effective Preparation of Plasmodium vivax Field Isolates for High-Throughput Whole Genome Sequencing (2013, neutral): “fasta] [10], and NCBI accession AB649419.”