Hippocampal sharp wave bursts coincide with neocortical "up-state" transitions.

By Francesco Battaglia, G. R. Sutherland, Bruce L. McNaughton. 2004

318 citations recorded by the source corpus.

The sleeping neocortex shows nested oscillatory activity in different frequency ranges, characterized by fluctuations between "up-states" and "down-states." High-density neuronal ensemble recordings in rats now reveal the interaction between synchronized activity in the hippocampus and neocortex: Electroencephalographic sharp waves in the hippocampus were more probable during down-states than during up-states, and tended to coincide with transitions from down-states to up-states. The form of cortical activity fluctuations and their interactions with sharp waves depend on sleep depth: In deeper sleep stages, characterized by strong neocortical oscillation in the delta range or slower (approximately 0.8-4 Hz), sharp-wave-triggered peri-event time histograms (PETH) are consistent with a longer duration for down-states than for up-states. In lighter sleep, the sharp-wave-triggered PETH suggested longer up-states than down-states. These results highlight the interplay in the hippocampal/neocortical loop: Decreased neocortical input during down-states may be a factor in generation of sharp waves. In turn, sharp waves may facilitate down-to-up transitions. This interplay may reflect joint memory trace reactivation in the hippocampus and in the neocortex, possibly contributing to consolidation of long-term memory: Off-line reactivation of recent neural activity patterns in the hippocampus occurs during 50-100-msec electroencephalographic sharp waves, corresponding to pyramidal-cell population bursts. The neocortical up-states starting in correspondence with sharp waves may be influenced by the reactivated information carried by the hippocampal sharp wave.

Subfields: Cognitive Neuroscience

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In Cognitive Neuroscience

Citations in the corpus

Replay in Deep Learning: Current Approaches and Missing Biological Elements (2021, neutral): “There is evidence for coordination between oscillations across the cortex and hippocampus (Battaglia, Sutherland, & McNaughton, 2004; Sirota, Csicsvari, Buhl, & Buzsáki, 2003; Mölle, Yeshenko, Marshall, Sara, & Born, 2006; Siapas & Wilson, 1998), suggesting that sleep rhythms can mediate the…”
Hippocampal replay of extended experience (2009, neutral): “…are also present during slowwave sleep, where they predominantly occur during periodic increases in neocortical population activity (‘‘up states’’) (Battaglia et al., 2004; Clemens et al., 2007; Mölle et al., 2006; Sirota et al., 2003) associated with slow oscillations in the cortical EEG…”
Bidirectional Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Spiking Activity During NREM Sleep. (2020, background): “In many studies, SWRs preferably occur during an Up-state (Isomura et al. 2006, Mölle et al. 2006, Nir et al. 2011), but see also (Battaglia et al. 2004, Hahn et al. 2007).”
State-dependent spike timing relationships between hippocampal and prefrontal circuits during sleep (2009, unknown): “5 Hz) or up and down states (Mölle et al., 2006; Hahn et al., 2006, 2007; Isomura et al., 2006; Battaglia et al., 2004; Sirota et al., 2003; Ji and Wilson, 2007).”
Neural syntax: cell assemblies, synapsembles and readers (2010, unknown): “, 2003), which can bias the spike content of hippocampal sharp wave ripples (Battaglia et al., 2004; Ji and Wilson, 2007).”
Synaptic Mechanisms of Memory Consolidation during Sleep Slow Oscillations (2016, background): “Several studies supported the hypothesis that SPW-R events occur mainly in the neocortical transition from Down to Up states (Battaglia et al., 2004), and suppression of hippocampal ripple results in poor performance in memory tasks (Ego-Stengel and Wilson, 2010).”
The hippocampal indexing theory and episodic memory: Updating the index (2007, background): “, 2007) and bursts of activity during sleep (Battaglia et al., 2004; Behrens et al., 2005).”
Methodological Considerations on the Use of Template Matching to Study Long-Lasting Memory Trace Replay (2006, background): “…that the spontaneous reactivation of memory-traces in the hippocampus during subsequent sleep may orchestrate memory consolidation in neocortical circuits (Marr, 1971; Buzsaki, 1989; Chrobak and Buzsaki, 1994; McClelland et al., 1995; Hoffman and McNaughton, 2002; Battaglia et al., 2004).”