The global burden of diabetic foot disease.

By A. Boulton, L. Vileikyte, G. Ragnarson-Tennvall, J. Apelqvist. The Lancet, 2005

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The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine. (2016, background): “This means that every 20 seconds, an amputation occurs in the world as an outcome of this debilitating disease.(4) Diabetic foot disease is common, and its incidence will only increase as the population ages and the obesity epidemic continues.”
Paracrine Factors of Mesenchymal Stem Cells Recruit Macrophages and Endothelial Lineage Cells and Enhance Wound Healing (2008, background): “Of over150 million people with diabetes, 15% suffer from chronic wounds [3,4].”
Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the U.K. (2011, background): “Neuropathy is one of the most common long-term complications of diabetes and is the main initiating factor for foot ulceration, Charcot neuroarthropathy, and lower-extremity amputation (1).”
Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis† (2017, background): “A previous study showed that a lower limb is amputated due to diabetes every 30 s (2), and the average annual cost of diabetic foot is $8659 per patient (3).”