ALCOHOL METABOLISM

By A. Cederbaum. Clinical Liver Disease, 2012

698 citations recorded by the source corpus.

This article describes the pathways and factors that modulate blood alcohol levels and metabolism and describes how the body disposes of alcohol. The various factors that play a role in the distribution of alcohol in the body, influence the absorption of alcohol, and contribute to first-pass metabolism of alcohol are described. Most alcohol is oxidized in the liver, and general principles and overall mechanisms for alcohol oxidation are summarized. The kinetics of alcohol elimination in-vivo and the various genetic and environmental factors that can modify the rate of alcohol metabolism are discussed.

Subfields: Epidemiology, Pathology and Forensic Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/71d019838818c0973c18d5f71dabedbc739c28b6

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In Epidemiology

1. M. Pinzani
2. M. Parola

In Pathology and Forensic Medicine

1. M. Pinzani
2. M. Parola

In Pharmacology

1. M. Pinzani
2. M. Parola

Citations in the corpus

• Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues. (2019, background): “…cytochrome P450 isoform, leading to acetaldehyde, increased ROS generation and oxidative stress-mediated injury (exacerbated by iron and hypoxia), mainly through lipid peroxidation affecting integrity of mitochondria and ER biomembranes (Lieber, 2004; Gao and Bataller, 2011; Cederbaum, 2012).”