Dendritic cell subsets in T cell programming: location dictates function

By S. Eisenbarth. Nature reviews. Immunology, 2018

709 citations recorded by the source corpus.

Dendritic cells (DCs) can be viewed as translators between innate and adaptive immunity. They integrate signals derived from tissue infection or damage and present processed antigen from these sites to naive T cells in secondary lymphoid organs while also providing multiple soluble and surface-bound signals that help to guide T cell differentiation. DC-mediated tailoring of the appropriate T cell programme ensures a proper cascade of immune responses that adequately targets the insult. Recent advances in our understanding of the different types of DC subsets along with the cellular organization and orchestration of DC and lymphocyte positioning in secondary lymphoid organs over time has led to a clearer understanding of how the nature of the T cell response is shaped. This Review discusses how geographical organization and ordered sequences of cellular interactions in lymph nodes and the spleen regulate immunity. Here, the author provides an overview of the spatial organization of the different subsets of dendritic cells in lymph nodes and spleen and discusses how the temporal microanatomy of secondary lymphoid organs allows for tailored and effective T cell immunity.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/7100fb0d3c15f07b26f129087d9a3183ce579abe

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In Immunology

1. S. Eisenbarth
2. M. Pittet
3. Daniel G. Tenen

Citations in the corpus

• Single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species (2019, background): “To assess hDC1–3, we compared their gene expression profiles to those of bulk-sorted classical DCs, which comprise cDC1 (defined as XCR1+ CADM1+ by flow cytometry) and cDC2 (CD1A+ CD172A+) (Eisenbarth, 2019; Guilliams et al., 2016). cDC1 are efficient antigen cross-presenters to CD8+ T cells, wherea”
• Structure-function of the immune system in the spleen (2019, background): “Innate immune cell function and organization Recognition of infection or host damage in the spleen activates a plethora of pattern recognition receptors (PRRs) on myeloid cells, which, in turn, induce requisite T cell activation signals on antigen- presenting cells (APCs), cytokine secretion, and pa”