Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

By W. Robinson, Christin M. Lepus, Qian Wang, H. Raghu, Rong Mao, T. Lindstrom, J. Sokolove. Nature Reviews Rheumatology, 2016

1,370 citations recorded by the source corpus.

Subfields: Oncology, Pharmacology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/70c8cb268af1beaa5b9f4a6e419d09346cf81e4a

How researchers see this paper

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In Oncology

1. D. Lieberman

In Pharmacology

1. David T Felson

Citations in the corpus

• Knee osteoarthritis has doubled in prevalence since the mid-20th century (2017, background): “Substantial evidence indicates that knee OA is proximately caused by the breakdown of joint tissues from mechanical loading (4) and inflammation (5), but the deeper underlying causes of knee OA’s high prevalence remain unclear and poorly tested, hindering efforts to prevent and treat the disease.”
• Damage-Associated Molecular Patterns in Inflammatory Diseases (2018, background): “However, emerging evidence suggests that DAMPs-induced inflammation plays an important role in the pathogenesis of OA (14,52,53).”