Origin and Function of Ubiquitin-like Protein Conjugation
By M. Hochstrasser. Nature, 2009
803 citations recorded by the source corpus.
Eukaryotic proteins can be modified through attachment to various small molecules and proteins. One such modification is conjugation to ubiquitin and ubiquitin-like proteins (UBLs), which controls an enormous range of physiological processes. Bound UBLs mainly regulate the interactions of proteins with other macromolecules, for example binding to the proteasome or recruitment to chromatin. The various UBL systems use related enzymes to attach specific UBLs to proteins (or other molecules), and most of these attachments are transient. There is increasing evidence suggesting that such UBL–protein modification evolved from prokaryotic sulphurtransferase systems or related enzymes. Moreover, proteins similar to UBL-conjugating enzymes and UBL-deconjugating enzymes seem to have already been widespread at the time of the last common ancestor of eukaryotes, suggesting that UBL–protein conjugation did not first evolve in eukaryotes.
View Paper: https://www.semanticscholar.org/paper/70a25dd916b0fe6e2c69c5f589500e3b6a1fb4ad
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Citations in the corpus
- The Logic of Chance: The Nature and Origin of Biological Evolution (2011, background): “For a long time, the ubiquitin signaling network that governs degradation and topogenesis of proteins within eukaryotic cells through the conjugation of a small, extremely conserved protein named ubiquitin (Ub) and much less common Ub paralogs to the target proteins has been considered a quintessent”
- Function and Regulation of SUMO Proteases (2012, background): “the proteasome (1) and/or at the proteasome (2).”
- Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein (2017, background): “Considering that ubiquitin-like modules are often involved in protein−protein interactions to regulate various biological processes (Hochstrasser, 2009), such as the MHV Ubl1−N interaction mentioned above, a novel possible function of Ub-like domains in CoVs might be the interaction with target…”
- Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving Towards a Model of Behavioral and Biological Mechanisms (2011, background): “PTMs can have a marked impact on cellular behavior by altering the dynamics of higher level processes like signal transduction, transcriptional efficiency, DNA replication, and cell cycle progression (Hochstrasser, 2009).”