Endemic and epidemic dynamics of cholera: the role of the aquatic reservoir
By C. Codeço. BMC Infectious Diseases, 2001
665 citations recorded by the source corpus.
BackgroundIn the last decades, attention to cholera epidemiology increased, as cholera epidemics became a worldwide health problem. Detailed investigation of V. cholerae interactions with its host and with other organisms in the environment suggests that cholera dynamics is much more complex than previously thought. Here, I formulate a mathematical model of cholera epidemiology that incorporates an environmental reservoir of V. cholerae. The objective is to explore the role of the aquatic reservoir on the persistence of endemic cholera as well as to define minimum conditions for the development of epidemic and endemic cholera.ResultsThe reproduction rate of cholera in a community is defined by the product of social and environmental factors. The importance of the aquatic reservoir depends on the sanitary conditions of the community. Seasonal variations of contact rates force a cyclical pattern of cholera outbreaks, as observed in some cholera-endemic communities.ConclusionsFurther development on cholera modeling requires a better understanding of V. cholerae ecology and epidemiology. We need estimates of the prevalence of V. cholerae infection in endemic populations as well as a better description of the relationship between dose and virulence.
Subfields: Endocrinology, Microbiology
View Paper: https://www.semanticscholar.org/paper/70967827b179dbaa1e9c5f612b4341fa412e1652
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Citations in the corpus
- Effects of Global Climate on Infectious Disease: the Cholera Model (2002, background): “prone to endemism? Torres Codeço (154) incorporated seasonality into a model of endemic cholera and showed that”
- The Theoretical Biologist's Toolbox: Quantitative Methods for Ecology and Evolutionary Biology (2006, background): “Second, the disease has a free-living stage, in stagnant water, that is key to transmission patterns (Codeço 2000).”
- Global Stability of Infectious Disease Models Using Lyapunov Functions (2013, background): “Thus the existing compartmental models for the transmission of waterborne diseases such as cholera normally have higher dimension than only directly transmitted diseases; see, for example, a basic cholera model in [5] consisting of four ordinary differential equations (ODEs).”