Post-translational modifications in the context of therapeutic proteins

By G. Walsh, R. Jefferis. Nature Biotechnology, 2006

968 citations recorded by the source corpus.

Subfields: Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/7026c2946a9a2103cc22f2f63de3de25fcf826db

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In Molecular Biology

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In Radiology, Nuclear Medicine and Imaging

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Citations in the corpus

• Optimal and consistent protein glycosylation in mammalian cell culture. (2009, background): “The molecule has exposed Man sugars, which facilitates macrophage recognition via mannose receptors on their cell surfaces (Walsh and Jefferis 2006).”
• Biopharmaceutical benchmarks 2010 (2010, background): “Glycoengineering The majority of therapeutic proteins display one or more post-translational modifications (PTMs), and these PTMs invariably influence the biochemical and therapeutic properties of such protein”