Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches

By Steffen Erhard Petersen, Paul M. Matthews, F. Bamberg, David A. Bluemke, J. Francis, M. Friedrich, Paul Leeson, E. Nagel, S. Plein, F. Rademakers and 6 more. 2013

254 citations recorded by the source corpus.

UK Biobank is a prospective cohort study with 500,000 participants aged 40 to 69. Recently an enhanced imaging study received funding. Cardiovascular magnetic resonance (CMR) will be part of a multi-organ, multi-modality imaging visit in 3–4 dedicated UK Biobank imaging centres that will acquire and store imaging data from 100,000 participants (subject to successful piloting). In each of UK Biobank’s dedicated bespoke imaging centres, it is proposed that 15–20 participants will undergo a 2 to 3 hour visit per day, seven days a week over a period of 5–6 years. The imaging modalities will include brain MRI at 3 Tesla, CMR and abdominal MRI at 1.5 Tesla, carotid ultrasound and DEXA scans using carefully selected protocols. We reviewed the rationale, challenges and proposed approaches for concise phenotyping using CMR on such a large scale. Here, we discuss the benefits of this imaging study and review existing and planned population based cardiovascular imaging in prospective cohort studies. We will evaluate the CMR protocol, feasibility, process optimisation and costs. Procedures for incidental findings, quality control and data processing and analysis are also presented. As is the case for all other data in the UK Biobank resource, this database of images and related information will be made available through UK Biobank’s Access Procedures to researchers (irrespective of their country of origin and whether they are academic or commercial) for health-related research that is in the public interest.

Subfields: Radiology, Nuclear Medicine and Imaging

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Citations in the corpus

Model-Based Generation of Large Databases of Cardiac Images: Synthesis of Pathological Cine MR Sequences From Real Healthy Cases (2018, background): “From the technical side, the interest is to support the design of computer-assisted methods that will tackle the processing of large databases with such sequences, such as the UK Biobank [6], eventually for the diagnosis of myocardial infarct.”
Multimodal population brain imaging in the UK Biobank prospective epidemiological study (2016, unknown): “While this might not provide statistical certainty for a diagnosis or interventional recommendation, it should allow for single-patient imaging to be used in a similar way to current state-of-the-art patient-tuned genetic testing.”
Protocol and quality assurance for carotid imaging in 100,000 participants of UK Biobank: development and assessment (2017, unknown): “participants over 6 years, including magnetic resonance imaging (MRI) scans of the brain, heart and body, a dual-energy X-ray absorptiometry (DEXA) scan and a carotid ultrasound.(2) The large scale and the richness of the phenotyping in UK Biobank allows researchers to examine aspects of cardiovascu”
Artificial Intelligence in Cardiovascular Imaging (2019, background): ““Biobanks” and “bioresources” are a particular form of organized “big data” collection usually as part of a formal research program with rigorous data collection and quality control (8,9).”
Weakly supervised classification of rare aortic valve malformations using unlabeled cardiac MRI sequences (2018, background): “The initial 72 release of UK Biobank imaging data includes cardiac MRI sequences for 14,328 73 subjects [14], including eight cardiac imaging sets.”
Statistical shape modeling of the left ventricle: myocardial infarct classification challenge (2017, background): “Quantification of the effects of risk factors and demographics on remodelling requires a large scale epidemiology study (for example, as is currently being performed in the UK Biobank [68]).”
Atlas-based Anatomical Modeling and Analysis of Heart Disease (2014, background): “Recently, an imaging extension to the UK Biobank has been announced, with cardiac, abdominal and brain MRI studies to be performed initially on a subset of 6,000 Biobank participants [4].”
Orthogonal decomposition of left ventricular remodeling in myocardial infarction (2017, methodology): “However, the methods developed in this work can be applied to future studies to track patients over time, or to epidemiological studies such as the Multi-Ethnic Study of Atherosclerosis [30] and the UK Biobank [31].”