Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a meta-analysis

By G. Clifford, Jennifer S. Smith, T. Aguado, Silvia Franceschi. British Journal of Cancer, 2003

722 citations recorded by the source corpus.

Particular types of human papillomavirus (HPV) infection may preferentially progress from high-grade squamous intraepithelial lesions (HSIL) to squamous cell carcinoma of the cervix (SCC). We performed a meta-analysis of published data to compare HPV type distribution in HSIL and SCC. HPV16, 18 and 45 were each more prevalent in SCC than HSIL, whereas the reverse was true for other oncogenic types including HPV31, 33, 52 and 58. These data suggest that HSILs infected with HPV16, 18 and 45 preferentially progress to SCC. This may have implications for follow-up protocols of future HPV-based cervical cancer screening programmes and for HPV vaccine trials.

Subfields: Epidemiology, Obstetrics and Gynecology, Surgery

View Paper: https://www.semanticscholar.org/paper/6fba945ace40390777bd9e1595c21e9487c1f1e4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Silvia Franceschi
2. G. Clifford
3. J. Doorbar

In Obstetrics and Gynecology

1. G. Clifford
2. Silvia Franceschi

In Surgery

1. Silvia Franceschi

Citations in the corpus

• Classification of papillomaviruses. (2004, background): “Some papillomatous proliferations induced by specific types of PVs bear a high risk for malignant progression (reviewed in Clifford et al., 2003; Munoz et al., 2003; Matsukura and Sugase, 2001; zur Hausen, 2002).”
• Human papillomavirus type distribution in invasive cervical cancer and high‐grade cervical lesions: A meta‐analysis update (2007, background): “–2Country not previously represented with ICC cases in Clifford et al., 2003 [ref.”