Reactive Oxygen Species in Metabolic and Inflammatory Signaling
By Steven J Forrester, Daniel S Kikuchi, M. Hernandes, Qian Xu, K. Griendling. Circulation Research, 2018
1,581 citations recorded by the source corpus.
Reactive oxygen species (ROS) are well known for their role in mediating both physiological and pathophysiological signal transduction. Enzymes and subcellular compartments that typically produce ROS are associated with metabolic regulation, and diseases associated with metabolic dysfunction may be influenced by changes in redox balance. In this review, we summarize the current literature surrounding ROS and their role in metabolic and inflammatory regulation, focusing on ROS signal transduction and its relationship to disease progression. In particular, we examine ROS production in compartments such as the cytoplasm, mitochondria, peroxisome and endoplasmic reticulum, and discuss how ROS influence metabolic processes such as proteasome function, autophagy and general inflammatory signaling. We also summarize and highlight the role of ROS in the regulation metabolic/inflammatory diseases including atherosclerosis, diabetes and stroke. To successfully develop improved therapies that target oxidative signaling, it is vital to understand the balance ROS signaling plays in both physiology and pathophysiology, and how manipulation of this balance and the identity of the ROS may influence cellular and tissue homeostasis. An increased understanding of specific sources of ROS production and an appreciation for how ROS influence cellular metabolism may help guide us in this effort to treat cardiovascular diseases.
Subfields: Epidemiology, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6f817f582470660992e68ce338acb412a1113f2a
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Citations in the corpus
- Mechanisms of Oxidative Stress in Metabolic Syndrome (2023, background): “Overproduction of ROS can occur in pathological disorders such as obesity, insulin resistance, hyperglycemia, chronic inflammation, and dyslipidemia [40,42,43].”
- The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. (2020, background): “Inflammatory mediators generated from bone, cartilage and synovial tissue activate chondrocytes and disrupt the homeostatic state, and the complete process is characterized by overproduction of ROS and mitochondrial dysfunction, overexpression of catabolismrelated genes and inflammation-related gene”