Molecular mechanisms of epistasis within and between genes.

By Ben Lehner. 2011

323 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. M. Pavličev
2. G. Diss
3. James M. Cheverud
4. Jian Peng
5. Huimin Zhao
6. Ben Lehner
7. Fyodor A. Kondrashov
8. Miriam Barlow

In Molecular Biology

1. G. Diss
2. M. Pavličev
3. James M. Cheverud
4. Jian Peng
5. Huimin Zhao
6. Wesley Wei Qian
7. Ben Lehner
8. Lam Vo

Citations in the corpus

• Evolutionary context-integrated deep sequence modeling for protein engineering (2020, background): “Evidence has shown that mutations within the sequence can have non-independent effects (epistasis) on fitness [43,55] .”
• A model of substitution trajectories in sequence space and long-term protein evolution. (2015, background): “Whether or not epistasis, a situation when fitness is dependent on the interaction of alleles, plays a major role in molecular evolution is the subject of scrutiny and debate (de Visser et al. 2011; Lehner 2011; Breen et al. 2012; Hansen 2013; McCandlish et al. 2013; de Visser and Krug 2014).”
• The genetic landscape of a physical interaction (2018, background): “an individual, making their effects difficult to predict (Lehner, 2011).”
• Evolving new protein-protein interaction specificity through promiscuous intermediates (2015, unknown): “…studies of epistasis typically consider the interdependence of individual substitutions with respect to protein folding or a single protein function (Kondrashov and Kondrashov, 2015; Lehner, 2011), our findings indicate that epistasis can also manifest at the level of interaction specificity.”
• Patterns of Epistasis between Beneficial Mutations in an Antibiotic Resistance Gene (2013, background): “Developmental and systems biologists seek to understand the physical, biochemical, and physiological causes of epistasis, whereas evolutionary biologists study its evolutionary consequences (Costanzo et al. 2010; de Visser et al. 2011; Lehner 2011; Wagner and Zhang 2011).”
• Constraints Evolve: Context Dependency of Gene Effects Allows Evolution of Pleiotropy (2015, background): “However, rooting population-level variational patterns in their underlying mechanisms is not a trivial undertaking (Lehner 2011, Olson-Manning et al. 2012).”