Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score.

By P. Ridker, J. Buring, N. Rifai, Nancy R. Cook. Journal of the American Medical Association (JAMA), 2007

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How researchers see this paper

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Obesity, inflammation, and atherosclerosis (2009, background): “Indeed, incorporating hsCRP, together with family history, into traditional risk prediction models has been shown to substantially improve global cardiovascular risk prediction in men and women”
Inflammation in Atherosclerosis: From Pathophysiology to Practice (2009, methodology): “(46,47) This observation suggests the importance of genetic factors as contributors to cardiovascular risk prediction not completely captured by the Framingham algorithm.”
History of Discovery: Inflammation in Atherosclerosis (2012, background): “The Reynolds risk score, in particular, adds hsCRP and family history of premature coronary artery disease to traditional risk factors in a clinically useful manner.(54) The successful application of biomarkers of inflammation to sharpen cardiovascular risk assessment, and its independence from trad”
The 2015 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension. (2013, methodology): “Several computerized methods have been developed for estimating total CV risk [41–48].”