The role of vitamin D in reducing cancer risk and progression

By D. Feldman, A. Krishnan, S. Swami, Edward L. Giovannucci, B. Feldman. Nature Reviews. Cancer, 2014

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How researchers see this paper

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American Cancer Society Guideline for Diet and Physical Activity for cancer prevention. (2020, neutral): “102 To date, the most consistent evidence for a cancer risk–lowering effect of vitamin D is for colorectal cancer.”
Oral squamous cell carcinomas: state of the field and emerging directions (2023, background): “Nutritional insufficiency, particularly in plant foods and vitamin D, is also related to an elevated potential of oral carcinomas.(65) Individuals with suppressed immune systems and rare hereditary diseases, such as Fanconi anemia (FA) and dyskeratosis congenital (DC), are more susceptible to OSCC t”
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. (2016, background): “This might not be surprising as the described SNPs only explain a small amount of the variation in 25(OH)D3 levels, and therefore the contribution of the specific SNPs to the predicted cancer risk may be too weak to be identified in genome-wide association studies (142).”
Transcriptomic profile induced by calcitriol in CaSki human cervical cancer cell line (2025, unknown): “Cell proliferation represents a pivotal biological process that undergoes negative regulation by calcitriol across various cell types [44].”
Vitamin D and Clinical Outcomes in Head and Neck Cancer: A Systematic Review (2025, unknown): “These findings are based on previous work by Feldman et al., who noted calcitriol’s potentiation of cisplatin cytotoxicity in HNSCC cells [54].”