Mode of antiviral action of silver nanoparticles against HIV-1
By H. H. Lara, N. V. Ayala-Nunez, L. Ixtepan-Turrent, C. Rodríguez-Padilla. Journal of Nanobiotechnology, 2010
1,000 citations recorded by the source corpus.
BackgroundSilver nanoparticles have proven to exert antiviral activity against HIV-1 at non-cytotoxic concentrations, but the mechanism underlying their HIV-inhibitory activity has not been not fully elucidated. In this study, silver nanoparticles are evaluated to elucidate their mode of antiviral action against HIV-1 using a panel of different in vitro assays.ResultsOur data suggest that silver nanoparticles exert anti-HIV activity at an early stage of viral replication, most likely as a virucidal agent or as an inhibitor of viral entry. Silver nanoparticles bind to gp120 in a manner that prevents CD4-dependent virion binding, fusion, and infectivity, acting as an effective virucidal agent against cell-free virus (laboratory strains, clinical isolates, T and M tropic strains, and resistant strains) and cell-associated virus. Besides, silver nanoparticles inhibit post-entry stages of the HIV-1 life cycle.ConclusionsThese properties make them a broad-spectrum agent not prone to inducing resistance that could be used preventively against a wide variety of circulating HIV-1 strains.
Subfields: Materials Chemistry, Virology
View Paper: https://www.semanticscholar.org/paper/6eec995f2242317d2d5194cdc89e67f3fece0ee8
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Citations in the corpus
- A review on plants extract mediated synthesis of silver nanoparticles for antimicrobial applications: A green expertise (2015, background): “These silver nanoparticles were evaluated to elucidate their mode of antiviral action against HIV-1 using a panel of different in vitro assays [78].”
- Metal-Based Nanoparticles as Antimicrobial Agents: An Overview (2020, background): “This problem was overcome by the conversion of CuNPs to CuONPs, the latter having greater stability but with slightly less activity [99].”
- Silver Nanoparticles as Potential Antiviral Agents (2011, methodology): “Human immunodeficiency virus type 1 (HIV1) Retroviridae PVP-coated silver nanoparticles (1–10 nm) Interaction with gp120 [38,39,40]”