Micronization of Ibuprofen by RESS

By Defne Kayrak, Ugur Akman, Ö. Hortaçsu. 2003

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Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability (2014, methodology): “Conventional methods of size reduction are usually known to have certain typical disadvantages of being less efﬁcient due to high energy requirements, posing threats of thermal and chemical degradation of drugs and the end products being not uniform in the particle size distribution [35,36].”