B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

By A. Ruffin, A. Cillo, T. Tabib, Angen Liu, Sayali S Onkar, S. Kunning, C. Lampenfeld, Huda I Atiya, I. Abécassis, Cornelius H. L. Kürten and 10 more. 2021

Subfields: Immunology, Otorhinolaryngology

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1. M. Knebel
2. Maximilian Linxweiler
3. S. Körner
4. L. Brust
5. S. Wemmert
6. J. Kühn
7. R. Bohle
8. B. Schick

Citations in the corpus

• Prognostic impact of intra- and peritumoral immune cell subpopulations in head and neck squamous cell carcinomas – comprehensive analysis of the TCGA-HNSC cohort and immunohistochemical validation on 101 patients (2023, background): “anti-PD1 and/ or anti-CTLA4 had significantly more naive B cells than responders, which indicates that driving naive TIL-B cells towards activated and germinal center phenotypes could be one way to complement current immunotherapeutic strategies also in head and neck cancer (41).”
• Immune Cell Abundance and T-cell Receptor Landscapes Suggest New Patient Stratification Strategies in Head and Neck Squamous Cell Carcinoma (2023, unknown): “Furthermore, these associations confirm findings on enriched ger-minalcenterB-cellsignatures andTLSsinHPV-positiveheadandnecktumors from Ruffin and colleagues (58).”