Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery.
By Zhuang Liu, Xiaoming Sun, Nozomi Nakayama-Ratchford, Hongjie Dai. ACS Nano, 2007
1,290 citations recorded by the source corpus.
We show that large surface areas exist for supramolecular chemistry on single-walled carbon nanotubes (SWNTs) prefunctionalized noncovalently or covalently by common surfactant or acid-oxidation routes. Water-soluble SWNTs with poly(ethylene glycol) (PEG) functionalization via these routes allow for surprisingly high degrees of pi-stacking of aromatic molecules, including a cancer drug (doxorubicin) with ultrahigh loading capacity, a widely used fluorescence molecule (fluorescein), and combinations of molecules. Binding of molecules to nanotubes and their release can be controlled by varying the pH. The strength of pi-stacking of aromatic molecules is dependent on nanotube diameter, leading to a method for controlling the release rate of molecules from SWNTs by using nanotube materials with suitable diameter. This work introduces the concept of "functionalization partitioning" of SWNTs, i.e., imparting multiple chemical species, such as PEG, drugs, and fluorescent tags, with different functionalities onto the surface of the same nanotube. Such chemical partitioning should open up new opportunities in chemical, biological, and medical applications of novel nanomaterials.
Subfields: Biomedical Engineering, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/6e6a3d750ada41df411d970affc0737ad9538abc
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In Materials Chemistry
Citations in the corpus
- Functionalized Carbon Nanotubes (CNTs) for Water and Wastewater Treatment: Preparation to Application (2021, background): “This new sort of man-made nano-material has a place with fullerene family and is treated as carbon’s third allotrope as well as sp2 and sp3 forms of graphite and diamond, respectively [42,48,49].”
- Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications (2016, background): “chemistry of amide or via hydrophobic non-covalent, supramolecular association between PEG-phospholipids and nanotubes.[95] PEGylation increases steric repulsion among the”