Perioperative beta-blocker therapy and mortality after major noncardiac surgery.

By P. Lindenauer, P. Pekow, Kaijun Wang, D. Mamidi, B. Gutierrez, Evan M. Benjamin. New England Journal of Medicine, 2005

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Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445] (2005, background): “A recent retrospective study illustrates the continued interest in the use of peri-operative βblockade in high-risk surgical patients [20], although the results of a multi-centre trial are still awaited [21].”
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. (2018, neutral): “This might have obscured the appraisal of a protective effect of treatment on the cognitive and functional decline of older hypertensive adults Syst-Eur Forette F, et al., 1998 (289) 9802273 Aim: Incident dementia Study type: RCT Size: 2,418 pts Duration: 2 y Inclusion criteria: ≥60 y Exclusion crit”
ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiov (2007, background): “A cohort study by Lindenauer et al (373) reviewed records from more than 700 000 patients undergoing noncardiac surgery at 329 hospitals in the United States.”