An emerging role for neutrophil extracellular traps in noninfectious disease

By Selina K. Jorch, P. Kubes. Nature Medicine, 2017

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DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. (2020, background): “These proteolytically coated chromatin entities are emerging as key regulators of neutrophil-mediated tissue injury, and they may contribute to the development of many noninfectious diseases (71).”
Dual-responsive biohybrid neutrobots for active target delivery (2021, background): “As a key mediator of the immune response, neutrophils (NEs) play an important role because of their activity in eliminating infectious threats through phagocytosis, degranulation, reactive oxygen species, and NE extracellular traps (NETs) (37, 38).”
Gasdermin D plays a vital role in the generation of neutrophil extracellular traps (2018, background): “These chromatin protein structures, called neutrophil ex tracellular traps (NETs), capture microorganisms, activate myeloid cells, and promote coagulation (13).”
Wound Healing: A Cellular Perspective. (2019, methodology): “Vital NETosis allows the neutrophils to stay alive and participate in subsequent functions such as phagocytosis.”
Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice (2018, background): “They do so via (i) phagocytosis, whereby bacteria or fungi are engulfed and digested; (ii) degranulation of cytotoxic enzymes and proteases into the extracellular space; or (iii) the formation of neutrophil extracellular traps (NETs)—scaffolds of chromatin with associated cytotoxic enzymes and prote”