Fast DNA translocation through a solid-state nanopore.

By A. Storm, C. Storm, Jianghua Chen, H. Zandbergen, J. Joanny, Cees Dekker. Nano letters (Print), 2004

660 citations recorded by the source corpus.

We report experiments and modeling of translocation of double-strand DNA through a siliconoxide nanopore. Long DNA molecules with different lengths ranging from 6500 to 97000 base pairs have been electrophoretically driven through a 10 nm pore. We observe a power-law caling of the translocation time with the length, with an exponent of 1.27. This nonlinear scaling is strikingly different from the well-studied linear behavior observed in similar experiments performed on protein pores. We present a theoretical model where hydrodynamic drag on the ection of the polymer outside the pore is the dominant force counteracting the electrical driving force. We show that this applies to our experiments, and we derive a power-law scaling with an exponent of 1.22, in good agreement with the data.

Subfields: Biomedical Engineering, Computational Mechanics, Physical and Theoretical Chemistry

View Paper: https://www.semanticscholar.org/paper/6e0cea16ebd47282604ba26df4e78914ff918569

How researchers see this paper

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In Biomedical Engineering

1. Michael Zwolak
2. M. Di Ventra
3. K. Murata
4. M. J. Kim
5. Ben Mcnally
6. M. Wanunu
7. Amit Meller

In Computational Mechanics

1. K. Murata
2. M. J. Kim
3. Ben Mcnally
4. Michael Zwolak
5. Amit Meller
6. M. Di Ventra

In Physical and Theoretical Chemistry

1. Michael Zwolak
2. M. Di Ventra

Citations in the corpus

• Characteristics of solid-state nanometre pores fabricated using a transmission electron microscope (2007, background): “Recent studies using solid state pores have begun to emerge, demonstrating the detection of double-stranded and single-stranded DNA conformations (Li et al 2003, Heng et al 2004, Storm et al 2005a, 2005b).”
• Electrostatic Focusing of Unlabeled DNA into Nanoscale Pores using a Salt Gradient (2009, background): “We consider equation (3) to be valid only for sufficiently long DNA, that is, N .”
• Colloquium: Physical approaches to DNA sequencing and detection (2007, background): “By considering a model that accounts for the driving electric force and the hydrodynamic drag force on the coiled-up polymer outside the pore, Storm et al., 2005b obtain a translocation duration that scales with polymer length as L1.”