The broad-spectrum antiviral functions of IFIT and IFITM proteins
By Michael S. Diamond, M. Farzan. Nature reviews. Immunology, 2012
862 citations recorded by the source corpus.
Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit infection by individual or multiple families of viruses. Among these IFN-stimulated genes with antiviral activity are two genetically and functionally distinct families — the IFN-induced protein with tetratricopeptide repeats (IFIT) family and the IFN-induced transmembrane protein (IFITM) family. This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses.
Subfields: Hepatology, Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/6ddc6feed8d1ca9b2fd7d1552215cdceabc73210
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Citations in the corpus
- Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients (2020, positive): “upregulated, including IFIT and IFITM genes that exert broadspectrum antiviral functions (IFIT1, -2, -3, and IFITM1, -2, -3) and others (ISG15 andRSAD2) (Diamond and Farzan, 2013; Helbig and Beard, 2014; Perng and Lenschow, 2018) (Figure 3B).”
- Interferon-Stimulated Genes: A Complex Web of Host Defenses (2014, background): “number of ISGs that inhibit translation, including zinc-finger antiviral protein (ZAP), the IFN-induced protein with tetratricopeptide repeats (IFIT) family, the OAS-RNaseL pathway, and PKR have been reviewed recently elsewhere (78, 155, 177, 178).”