Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa
By N. Feasey, Gordon Dougan, R. Kingsley, R. Heyderman, M. Gordon. The Lancet, 2012
999 citations recorded by the source corpus.
Summary Invasive strains of non-typhoidal salmonellae have emerged as a prominent cause of bloodstream infection in African adults and children, with an associated case fatality of 20–25%. The clinical presentation of invasive non-typhoidal salmonella disease in Africa is diverse: fever, hepatosplenomegaly, and respiratory symptoms are common, and features of enterocolitis are often absent. The most important risk factors are HIV infection in adults, and malaria, HIV, and malnutrition in children. A distinct genotype of Salmonella enterica var Typhimurium, ST313, has emerged as a new pathogenic clade in sub-Saharan Africa, and might have adapted to cause invasive disease in human beings. Multidrug-resistant ST313 has caused epidemics in several African countries, and has driven the use of expensive antimicrobial drugs in the poorest health services in the world. Studies of systemic cellular and humoral immune responses in adults infected with HIV have revealed key host immune defects contributing to invasive non-typhoidal salmonella disease. This emerging pathogen might therefore have adapted to occupy an ecological and immunological niche provided by HIV, malaria, and malnutrition in Africa. A good understanding of the epidemiology of this neglected disease will open new avenues for development and implementation of vaccine and public health strategies to prevent infections and interrupt transmission.
Subfields: Endocrinology, Food Science, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/6d9d797feaac5f170b226dfe9120bf26f553293a
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Food Science
In Infectious Diseases
Citations in the corpus
- Salmonella enterica Serovar Typhimurium Skills To Succeed in the Host: Virulence and Regulation (2013, background): “A feared complication of Salmonella bacteremia in adults is the development of infectious endarteritis, especially that which involves the abdominal aorta (19, 29, 31).”