Normalization of Lactulose Breath Testing Correlates With Symptom Improvement in Irritable Bowel Syndrome: A Double-Blind, Randomized, Placebo-Controlled Study

By M. Pimentel, E. Chow, Henry C. Lin. American Journal of Gastroenterology, 2003

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Analysis of the Fecal Microbiota of Irritable Bowel Syndrome Patients and Healthy Controls with Real-Time PCR (2005, background): “In a recent study, constipation predominant subjects showed an increased tendency for methane excretion whereas diarrhea predominant subjects did not excrete methane; furthermore, the severity of the constipation had a positive correlation with methane excretion (8).”
Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions (2010, background): “Some studies have suggested that small intestinal bacterial overgrowth (SIBO), for example, is frequent among patients with IBS”
Efficacy of an Encapsulated Probiotic Bifidobacterium infantis 35624 in Women with Irritable Bowel Syndrome (2006, background): “coupled with reports of abnormal colonization of the small bowel in some patients (14, 15), suggests that it is possible that alterations in the bacterial flora of the gut may be of relevance.”