The functions and unique features of long intergenic non-coding RNA
By J. Ransohoff, Yuning Wei, P. Khavari. Nature reviews. Molecular cell biology, 2017
1,176 citations recorded by the source corpus.
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity. Some genes currently annotated as encoding lincRNAs include small open reading frames (smORFs) and encode functional peptides and thus may be more properly classified as coding RNAs. lincRNAs may broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity through a diversity of mechanisms, highlighting our rapidly evolving understanding of the non-coding genome.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6d11d4772ea2fc841202356a9ba1bca1e14772ae
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In Cancer Research
In Molecular Biology
Citations in the corpus
- Long Non-Coding RNA in the Pathogenesis of Cancers (2019, background): “So far, the functions of only a very few number of lncRNAs have been annotated [14,15], and various methodologies have been developed to explore the expression, distribution, and function of lncRNAs (Table 1).”