Mass-spectrometric exploration of proteome structure and function

By R. Aebersold, Matthias Mann. Nature, 2016

1,968 citations recorded by the source corpus.

Subfields: Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/6d064b8d120f6c0182041a440b75031b08d9aed6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Spectroscopy

Citations in the corpus

Online Parallel Accumulation–Serial Fragmentation (PASEF) with a Novel Trapped Ion Mobility Mass Spectrometer (2018, neutral): “These co-eluting peptides with abundances ranging over many orders of magnitude present a formidable analytical challenge, which has constantly pushed the development of faster and more sensitive instrumentation over the last decades (1, 3, 6, 7).”
Data‐independent acquisition‐based SWATH‐MS for quantitative proteomics: a tutorial (2018, positive): “Over the last decades, liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) has become the technology of choice for the high-throughput characterization of proteins and proteomes (Aebersold & Mann, 2016).”
Proteomic and Metabolomic Characterization of COVID-19 Patient Sera (2020, methodology): “To test this hypothesis, we applied cutting-edge proteomic 72 (Aebersold and Mann, 2016; Li et al., 2020a) and metabolomic (Hou et al.”
Revisiting biomarker discovery by plasma proteomics (2017, methodology): “In principle, MS-based proteomics can analyze all the proteins in a system—its proteome—and is in this sense unbiased and hypothesis-free (Aebersold & Mann, 2016).”
The Need for Multi-Omics Biomarker Signatures in Precision Medicine (2019, background): “This includes fields such as transcriptomics (the study of the expression of all genes in a cell or organism [2–4], proteomics (the analysis of all proteins, [5,6]), metabolomics (the comprehensive analysis of all small molecules, [7,8]), and epigenomics (the study of the epigenetic regulation of th”
Integrated Omics: Tools, Advances, and Future Approaches. (2019, background): “…while decreasing the amount of sample required for high-throughput analyses and now allow for the detection of minimal differences in protein abundances, identification of post-translational modifications and other applications from a wide range of samples and tissues (Aebersold & Mann 2016).”
Sex estimation using sexually dimorphic amelogenin protein fragments in human enamel (2019, background): “The peptides are converted from being in solution to gas phase using electrospray ionization, which gently removes the surrounding liquid and adds a positive charge (Aebersold and Mann, 2016).”
IonQuant Enables Accurate and Sensitive Label-Free Quantification With FDR-Controlled Match-Between-Runs (2020, methodology): “A mixture model (Equation (3)) is built using type 1 and −1 ions, and the expectation-maximization (EM) algorithm is used to fit the model and subsequently calculate the posterior probability.”