The Presynaptic Active Zone
By T. Sūdhof. Neuron, 2012
1,014 citations recorded by the source corpus.
Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a presynaptic nerve terminal. In this review, I discuss the molecular composition and function of the active zone. Active zones are composed of an evolutionarily conserved protein complex containing as core constituents RIM, Munc13, RIM-BP, α-liprin, and ELKS proteins. This complex docks and primes synaptic vesicles for exocytosis, recruits Ca2+ channels to the site of exocytosis, and positions the active zone exactly opposite to post-synaptic specializations via transsynaptic cell-adhesion molecules. Moreover, this complex mediates short- and long-term plasticity in response to bursts of action potentials, thus critically contributing to the computational power of a synapse.
Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6ce5ba42a726cbd7a2cfc4441578765dadd4b913
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Citations in the corpus
- Multi-trait analysis of genome-wide association summary statistics using MTAG (2018, neutral): “For example, PCLO , BSN , SNAP25 , and CACNA1E all encode important parts of the machinery that releases neurotransmitter from the signaling neuron 17 .”
- Neuropeptide transmission in brain circuits (2012, background): “Neuropeptide release Scientists have a keen insight into the temporal sequence and many of the molecules involved in the release of fast neurotransmitters at presynaptic specializations (Sudhof, 2012).”