Polymer translocation through a long nanopore
By E. Slonkina, A. Kolomeisky. 2002
184 citations recorded by the source corpus.
Polymer translocation through a nanopore in a membrane is investigated theoretically. Recent experiments on voltage-driven DNA and RNA translocations through a nanopore indicate that the size and geometry of the pore are important factors in polymer dynamics. A theoretical approach is presented which explicitly takes into account the effect of the nanopore length and diameter for polymer motion across the membrane. It is shown that the length of the pore is crucial for polymer translocation dynamics. The present model predicts that for realistic conditions (long nanopores and large external fields) there are two regimes of translocation depending on polymer size: for polymer chains larger than the pore length, the velocity of translocation is nearly constant, while for polymer chains smaller than the pore length the velocity increases with decreasing polymer size. These results agree with experimental data.
Subfields: Biomedical Engineering, Molecular Biology, Physical and Theoretical Chemistry
View Paper: https://www.semanticscholar.org/paper/6c5a8ddbd1efeb7e843f2534eff1ce90c56e186d
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In Biomedical Engineering
In Molecular Biology
In Physical and Theoretical Chemistry
Citations in the corpus
- Colloquium: Physical approaches to DNA sequencing and detection (2007, methodology): “…and applied field (Ambjörnsson et al., 2002; Chern et al., 2001; Chuang et al., 2002; Kong and Muthukumar, 2002; Loebl et al., 2003; Lubensky and Nelson, 1999; Luo et al., 2006; Matysiak et al., 2006; Meller, 2003; Muthukumar, 1999, 2001; Slonkina and Kolomeisky, 2003; Sung and Park, 1996).”
- Transport phenomena in nanofluidics (2008, background): “Muthukumar, 2001, 2003; Slonkina and Kolomeisky, 2003; Ghosal, 2007" and simulations of the sizing !”