The path of messenger RNA through the ribosome.

By G. Yusupova, M. Yusupov, J. H. D. Cate, H. Noller. Cell, 2001

602 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6c27532f24dec4ed34c0ad1f0056bf3d215c139f

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In Molecular Biology

Citations in the corpus

MicroRNA targeting specificity in mammals: determinants beyond seed pairing. (2007, background): “The length of $15 nt was in agreement with the observation that mRNA enters the ribosome $15 nt downstream of the decoding site (Yusupova et al., 2001; Takyar et al., 2005), which would presumably strip off any silencing complex and block rebinding until the ribosome dissociated from the message.”
Studies on the structure-function relationship of the bacterial ribosome (2004, methodology): “The path of the mRNA in the 70S ribosomes has been studied by mediumresolution (5–7 Å) X-ray crystallography (Yusupova et al. 2001, Yusupov et al. 2001).”
Regulation of translation via mRNA structure in prokaryotes and eukaryotes. (2005, background): “The spacing requirement can be rationalized by structural models of the ribosome which show the P site, where AUG binds, on the interface side of the 30S subunit while the “anti-SD sequence” in 16S rRNA is around the corner, on the solvent side (Yusupova et al., 2001).”
The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome. (2007, background): “mRNA Exit Channel mRNA leaves the ribosome through the mRNA exit channel, formed by interaction of rpS14 and rpS5 (Yusupova et al., 2001).”
RNA synthetic biology (2006, background): “In bacteria, several factors affect translation initiation, including ribosomal recognition of the mRNA ribosome-binding site (RBS”
Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex. (2006, methodology): “Its similarity to the mRNA path on the 70S ribosome as determined by crystallography (Yusupova et al. 2001) justifies using the structure of the mRNA/30S subunit complex to model our cross-linking data.”
Studies on the role of helix 69 of 23S rRNA in the factor-dependent stages of translation initiation, elongation, and termination (2011, background): “…complex undergoes a conformational rearrangement and the region of mRNA downstream of the Shine-Dalgarno sequence is located into the mRNA channel where the AUG start codon is ready to bind the initiator tRNA in the P-site (Yusupova et al. 2001; Yusupova et al. 2006; Kaminishi et al. 2007).”