Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.

By E. Prossnitz, J. B. Arterburn, H. Smith, Tudor I. Oprea, L. Sklar, H. Hathaway. Annual Review of Physiology, 2008

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Estrogen Rapidly Enhances Incisional Pain of Ovariectomized Rats Primarily through the G Protein-Coupled Estrogen Receptor (2014, background): “As a member of the G protein coupled receptor (GPCR) family, GPER has a 7-transmembrane hydrophobic domain, which consists of 20–26 amino acids interconnected by six alternating extracellular and intracellular loops [26].”
The mammalian ovary from genesis to revelation. (2009, background): “A membrane-bound G protein-coupled receptor, GPR30 (Gper), might mediate rapid, nongenomic estradiol signaling (297) and is implicated in maintenance of meiotic arrest in fish oocytes (298).”
The G protein-coupled estrogen receptor GPER in health and disease (2011, background): “Our understanding of the widespread physiological effects of 17β-estradiol is complicated by the existence of several types of estrogen receptors (ERs) and multiple modes of cellular signaling mechanisms that span time frames from seconds to hours, or even days”
Hypertension Renin–Angiotensin–Aldosterone System Alterations (2015, background): “Besides its genomic effects mediated by stimulation of the MR receptors in the kidney and vasculature, rapid nongenomic effects of aldosterone have also been reported.91 These nongenomic effects of aldosterone may be mediated by GPER.91,104 GPER is a widely distributed receptor, also identified in E”