Proteolysis: from the lysosome to ubiquitin and the proteasome
By Aaron Ciechanover. Nature reviews. Molecular cell biology, 2005
1,150 citations recorded by the source corpus.
Subfields: Cell Biology, Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6bdbfd078f2d4b39812d8969d1cf06f36ed7a9e3
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In Cell Biology
In Epidemiology
In Molecular Biology
- P. Pandolfi
- Paul Tempst
- H. Erdjument‐Bromage
- Asfar S. Azmi
- Robert Blelloch
- Stephen P. Jackson
- G. Russo
- Xuejun Jiang
Citations in the corpus
- Ubiquitination regulates PTEN nuclear import and tumor suppression. (2007, background): “PTEN polyubiquitination, in contrast, leads to its cytoplasmic retention and degradation (Ciechanover, 2005) and is therefore oncogenic in nature (see also Wang et al.”
- Deubiquitylating enzymes and drug discovery: emerging opportunities (2017, background): “Deubiquitylating enzymes and drug discovery: emerging opportunities Jeanine A. Harrigan 1 *, Xavier Jacq 1 *, Niall M. Martin 1, 2 , and Stephen P. Jackson 1, 3 Abstract | More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitinproteasome system and clinical approval of ”
- Broad targeting of resistance to apoptosis in cancer (2015, background): “5 MDa large complex conisting of two 19S regulatory particles and one 20S catalytic ore [101].”
- Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory (2019, background): “The two main pathways for protein degradation are the lysosome and the proteasome (Ciechanover, 2005).”
- Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, neutral): “Hence, their dysfunction contributes to pathogeneses of neurodegenerative diseases (Ciechanover, 2005; Rubinsztein, 2006).”
- Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. (2005, background): “The 26S proteasome plays a critical role in cellular homeostasis through its function in ubiquitin-dependent protein turnover, including targets involved in cell cycle progression, apoptosis, DNA repair, stress response, and misfolded and obsolete proteins.(1) Major catalytic activities of the 20S c”