Angiocrine functions of organ-specific endothelial cells
By Shahin Rafii, J. Butler, B. Ding. Nature, 2016
842 citations recorded by the source corpus.
Endothelial cells that line capillaries are not just passive conduits for delivering blood. Tissue-specific endothelium establishes specialized vascular niches that deploy sets of growth factors, known as angiocrine factors. These cues participate actively in the induction, specification, patterning and guidance of organ regeneration, as well as in the maintainance of homeostasis and metabolism. When upregulated following injury, they orchestrate self-renewal and differentiation of tissue-specific resident stem and progenitor cells into functional organs. Uncovering the mechanisms by which organotypic endothelium distributes physiological levels of angiocrine factors both spatially and temporally will lay the foundation for clinical trials that promote organ repair without scarring.
Subfields: Cancer Research, Pulmonary and Respiratory Medicine, Surgery
View Paper: https://www.semanticscholar.org/paper/6b1efd5ca5b8c303aeb38b0136317a41f275d2d0
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
Citations in the corpus
- Tissue Engineering for Clean Meat Production (2019, background): “, 2007) and regulate skeletal muscle tissue regeneration and maturation through angiocrine signaling (Figure 1) (Christov et al., 2007; Butler et al., 2010; Koffler et al., 2011; Rafii et al., 2016).”
- Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology (2017, background): “Transplantation of properly activated lung capillary ECs or injection of lung-specific angiocrine mediators could therefore emerge as a therapeutic modality to drive epithelial cell repopulation and improve respiratory function (3, 45).”