Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

By L. Jordheim, D. Durantel, F. Zoulim, Charles Dumontet. Nature reviews. Drug discovery, 2013

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Regulation of mammalian nucleotide metabolism and biosynthesis (2015, background): “Despite its functional importance, nucleotide metabolism and cell cycle control have received much less attention than genomics and functional genomics, although there have been multiple metabolic targets derived from the relevant processes for human disease therapy, such as the antimetabolites MTX ”
Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “The first telomerase inhibitor to be reported has been the 3-Azido-2,3-dideoxythymidine (azidothymidine or zidovudine) (144) and results from phase I and II clinical trials of azidothymidine alone or in combination have shown some rate of regression in different solid tumors (170).”