Nuclear Receptors, RXR & the Big Bang

By R. Evans, D. Mangelsdorf. Cell, 2014

1,046 citations recorded by the source corpus.

Summary Isolation of genes encoding the receptors for steroids, retinoids, vitamin D and thyroid hormone, and their structural and functional analysis revealed an evolutionarily conserved template for nuclear hormone receptors. This discovery sparked identification of numerous genes encoding related proteins, termed orphan receptors. Characterization of these orphan receptors, and in particular of the retinoid X receptor (RXR), positioned nuclear receptors at the epicenter of the “Big Bang” of molecular endocrinology. This review provides a personal perspective on nuclear receptors and explores their integrated and coordinated signaling networks that are essential for multi-cellular life, highlighting the RXR heterodimer and its associated ligands and transcriptional mechanism.

Subfields: Cellular and Molecular Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6acd4d1ef112b4d50d9ec254f873a572b4104a7a

Citations in the corpus

• Toward Minimal Residual Disease-Directed Therapy in Melanoma. (2018, neutral): “RXR functions primarily by heterodimerizing with and regulating the activity of a dozen of nuclear receptors (Evans and Mangelsdorf, 2014).”