Growth Arrest and DNA Damage-Inducible Protein GADD34 Targets Protein Phosphatase 1α to the Endoplasmic Reticulum and Promotes Dephosphorylation of the α Subunit of Eukaryotic Translation Initiation…

By Matthew H. Brush, Douglas Weiser, S. Shenolikar. Molecular and Cellular Biology, 2003

413 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6ab2bc2a624ee0059453400c8aed9391d1e67e0d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. R. Kaufman
2. D. Ron
3. H. Harding
4. Afshin Samali
5. A. Gorman
6. S. Oyadomari
7. S. Marciniak
8. I. Novoa

In Molecular Biology

1. D. Ron
2. H. Harding
3. R. Kaufman
4. Afshin Samali
5. A. Gorman
6. I. Novoa
7. Junying Yuan
8. Yuhong Zhang

Citations in the corpus

• From promiscuity to precision: protein phosphatases get a makeover. (2009, background): “For example, the muscle glycogenbinding subunit (Johnson et al., 1996) and myosin-binding subunit (Alessi et al., 1992) preferentially recruit the PP1b isoform, while neurabins bind PP1g1 (MacMillan et al., 1999) and the translational regulator GADD34 binds PP1a (Brush et al., 2003).”
• Endoplasmic reticulum stress signaling in disease. (2006, background): “The induction of GADD34 in particular appears central to the reversal of stress-induced translational attenuation (18, 87, 114, 131, 132).”
• CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. (2004, background): “GADD34 encodes a regulatory subunit of an eIF2 -directed phosphatase complex that promotes recovery of CHOP and ER stress GENES & DEVELOPMENT 3067 protein synthesis in cells exposed to ER stress (Connor et al. 2001; Novoa et al. 2001, 2003; Brush et al. 2003).”
• Mediators of endoplasmic reticulum stress‐induced apoptosis (2006, background): “GADD34 is a protein phosphatase 1 (PP1)-interacting protein that causes PP1 to dephosphorylate eIF2 and thus release the translational block (Brush et al, 2003).”
• Cellular response to endoplasmic reticulum stress: a matter of life or death (2006, background): “lation mediated by the general cellular serine/threonine phosphatase protein phosphatase 1 (PP1).(117,118) The catalytic subunit of PP1 shows little, if any, intrinsic substrate”