KEGG mapping tools for uncovering hidden features in biological data
By Minoru Kanehisa, Yoko Sato, Masayuki Kawashima. Protein Science, 2021
616 citations recorded by the source corpus.
In contrast to artificial intelligence and machine learning approaches, KEGG (https://www.kegg.jp) has relied on human intelligence to develop “models” of biological systems, especially in the form of KEGG pathway maps that are manually created by capturing knowledge from published literature. The KEGG models can then be used in biological big data analysis, for example, for uncovering systemic functions of an organism hidden in its genome sequence through the simple procedure of KEGG mapping. Here we present an updated version of KEGG Mapper, a suite of KEGG mapping tools reported previously (Kanehisa and Sato, Protein Sci 2020; 29:28–35), together with the new versions of the KEGG pathway map viewer and the BRITE hierarchy viewer. Significant enhancements have been made for BRITE mapping, where the mapping result can be examined by manipulation of hierarchical trees, such as pruning and zooming. The tree manipulation feature has also been implemented in the taxonomy mapping tool for linking KO (KEGG Orthology) groups and modules to phenotypes.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6aa99d38d5851c217f3beffb26815f549c60d9c1
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In Molecular Biology
- Minoru Kanehisa
- Yoko Sato
- Miho Furumichi
- Masayuki Kawashima
- Mari Ishiguro-Watanabe
- Mao Tanabe
- Mehmet Gönen
- David S. Wishart
Citations in the corpus
- KEGG for taxonomy-based analysis of pathways and genomes (2022, methodology): “The KEGG model has the practical benefit of helping to uncover hidden features in large-scale biological data (2), such as cellular and organism-level functions hidden in genome and metagenome sequences.”
- KEGG: biological systems database as a model of the real world (2024, neutral): “KEGG Mapper is a collection of KEGG mapping tools, which started as a simple tool for searching and coloring pathway maps at the beginning of the KEGG project and was significantly expanded over the years ( 5 ,6 ).”