A chemokine-driven positive feedback loop organizes lymphoid follicles

By K. Ansel, Vu N. Ngo, P. Hyman, S. Luther, R. Förster, J. Sedgwick, J. Browning, M. Lipp, J. Cyster. Nature, 2000

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Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function (2000, positive): “In mice, the lack of CXCR5 or BLC (the murine homologue of human BCA-1) resulted in abnormal lymphoid tissue formation (17, 18), notably follicular organization in the spleen and PPs, whereas transgenic mice expressing BLC in pancreatic islets showed secondary lymphoid tissue–like structures at thes”
Subspecialization of Cxcr5+ T Cells (2001, neutral): “BLC is required for B cell migration to follicles in lymph nodes and spleen (29).”
Tumor-infiltrating lymphocytes in the immunotherapy era (2020, background): “The CXCL13–CXCR5 axis regulates the organization of B cells inside the follicles of lymphoid tissues.(164) Interestingly, Thommen et al.”
Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers (2004, neutral): “…chemokines for spleen develop- ment include: ELC and SLC, ligands for the chemokine receptor CCR7; BLC, which binds CXCR5 (Forster et al, 1999; Ansel et al, 2000) and SDF-1, which promotes traffick- ing of both immature and naı̈ve lymphocytes to lymphoid tissues (Kim and Broxmeyer, 1999).”