The role of protein dynamics in the evolution of new enzyme function.

By E. Campbell, Miriam Kaltenbach, G. Correy, P. Carr, Benjamin T. Porebski, E. Livingstone, Livnat Afriat-Jurnou, Ashley M. Buckle, M. Weik, F. Hollfelder and 2 more. 2016

291 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Materials Chemistry

1. M. Grimaldo
2. F. Roosen‐Runge
3. Diego del Alamo
4. Jens Meiler
5. Fajun Zhang
6. Frank Schreiber
7. Davide Sala
8. T. Seydel

In Molecular Biology

1. M. Grimaldo
2. F. Roosen‐Runge
3. Diego del Alamo
4. Jens Meiler
5. Miquel Estévez-Gay
6. Sílvia Osuna
7. Fajun Zhang
8. C. Duran

Citations in the corpus

• Sampling alternative conformational states of transporters and receptors with AlphaFold2 (2022, background): “Dynamic interconversion between multiple conformations underpins the functions of integral membrane proteins in all domains of life ( Campbell et al., 2016 ; Cournia et al., 2015 ; Shaw et al., 2010 ; Boehr et al., 2009 ).”
• Estimating conformational heterogeneity of tryptophan synthase with a template‐based Alphafold2 approach (2022, background): “2, 13 In this work, we evaluate the potential of AF2 for quickly estimating the conformational heterogeneity of different TrpB displaying different levels of stand-alone activity.”
• Dynamics of proteins in solution (2019, background): “…and the folding state, leading typically to a few-nanometer-sized objects in the case of globular proteins, the dynamics is key to fulfill their function (Frauenfelder, 1998; Zaccai, 2000; Henzler-Wildman et al., 2007; Richter, 2012; Yang et al., 2014; Campbell et al., 2016; Hong et al., 2016).”