Degeneration of the intervertebral disc
By J. Urban, S. Roberts. Arthritis Research & Therapy, 2003
1,286 citations recorded by the source corpus.
The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body. It is believed to be important clinically because there is an association of disc degeneration with back pain. Current treatments are predominantly conservative or, less commonly, surgical; in many cases there is no clear diagnosis and therapy is considered inadequate. New developments, such as genetic and biological approaches, may allow better diagnosis and treatments in the future.
Subfields: Cell Biology, Pathology and Forensic Medicine, Pharmacology
View Paper: https://www.semanticscholar.org/paper/6a1d8edee51046a9b4ba2f64c0358a891d7b5369
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In Pathology and Forensic Medicine
In Pharmacology
Citations in the corpus
- What is Intervertebral Disc Degeneration, and What Causes It? (2006, background): “Loss of proteoglycan fragments from the disc is a slow process owing to the entrapment of the nucleus by the fibrous anulus and the cartilage endplates of the vertebrae.[37] As long as the proteoglycan fragments remain entrapped in the disc, they can fulfill a functional role similar to that of the ”