A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

By R. Black, C. Rauch, C. Kozlosky, J. Peschon, J. Slack, M. Wolfson, B. Castner, K. Stocking, P. Reddy, S. Srinivasan and 10 more. 1997

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Essential roles of Meltrin β (ADAM19) in heart development (2004, background): “Tumor Necrosis Factor-a (TNF-a) converting enzyme (TACE) (ADAM17) converts various membrane proteins such as TNF-a and Transforming Growth Factor (TGF)-a from their membrane-bound to soluble forms (Black et al., 1997; Moss et al., 1997; Peschon et al., 1998).”
Matrix metalloproteinases as modulators of inflammation. (2008, background): “TNF-α is expressed on Tcells and macrophages as a 26 kDa membrane-bound protein (pro-TNF-α) that is activated by cleavage to a 17 kDa soluble cytokine by TNF converting enzyme (TACE), identical to ADAM17, a member of the disintegrin family of metalloproteinases [29,30].”
Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch (1997, methodology): “Antibodies againstwhich is released from the plasma membrane by the both proteins can inhibit fertilization and bind to spermTNFa convertase (TACE; Black et al., 1997; Moss et in indirect immunofluorescence experiments, thus pro-al., 1997), and Drosophila Notch, which apparently is viding the first…”