Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

By Marta Pajares, Ana I Rojo, G. Manda, L. Boscá, A. Cuadrado. Cells, 2020

654 citations recorded by the source corpus.

Parkinson’s disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia nigra pars compacta. Although the molecular bases for PD development are still little defined, extensive evidence from human samples and animal models support the involvement of inflammation in onset or progression. However, the exact trigger for this response remains unclear. Here, we provide a systematic review of the cellular mediators, i.e., microglia, astroglia and endothelial cells. We also discuss the genetic and transcriptional control of inflammation in PD and the immunomodulatory role of dopamine and reactive oxygen species. Finally, we summarize the preclinical and clinical approaches targeting neuroinflammation in PD.

Subfields: Cellular and Molecular Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/69f59fc5fb4d8fe659c99e5f8debb7a2e6ab50cf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Physiology

1. Dan Xiao
2. Weifeng Zhang
3. Haibin Xia
4. Q. Mao

Citations in the corpus

• Role of neuroinflammation in neurodegeneration development (2023, background): “These results show that constitutive deletion of P2X7 aggravates ALS pathogenesis, indicating that the P2X7 signaling may have a dual role in the development of ALS and the importance of time window for therapeutic intervention.387 Recently, P2X7 was found to be a scavenger receptor in the absence o”