Exercise treatment for depression: efficacy and dose response.
By A. Dunn, Madhukar H. Trivedi, J. Kampert, C. G. Clark, H. Chambliss. American Journal of Preventive Medicine, 2005
1,410 citations recorded by the source corpus.
BACKGROUND This study, conducted between 1998 and 2001 and analyzed in 2002 and 2003, was designed to test (1) whether exercise is an efficacious treatment for mild to moderate major depressive disorder (MDD), and (2) the dose-response relation of exercise and reduction in depressive symptoms. DESIGN The study was a randomized 2x2 factorial design, plus placebo control. SETTING/PARTICIPANTS All exercise was performed in a supervised laboratory setting with adults (n =80) aged 20 to 45 years diagnosed with mild to moderate MDD. INTERVENTION Participants were randomized to one of four aerobic exercise treatment groups that varied total energy expenditure (7.0 kcal/kg/week or 17.5 kcal/kg/week) and frequency (3 days/week or 5 days/week) or to exercise placebo control (3 days/week flexibility exercise). The 17.5-kcal/kg/week dose is consistent with public health recommendations for physical activity and was termed "public health dose" (PHD). The 7.0-kcal/kg/week dose was termed "low dose" (LD). MAIN OUTCOME MEASURES The primary outcome was the score on the 17-item Hamilton Rating Scale for Depression (HRSD(17)). RESULTS The main effect of energy expenditure in reducing HRSD(17) scores at 12 weeks was significant. Adjusted mean HRSD(17) scores at 12 weeks were reduced 47% from baseline for PHD, compared with 30% for LD and 29% for control. There was no main effect of exercise frequency at 12 weeks. CONCLUSIONS Aerobic exercise at a dose consistent with public health recommendations is an effective treatment for MDD of mild to moderate severity. A lower dose is comparable to placebo effect.
Subfields: Physiology, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/69c6fecab74e02ba26b5b27a3aa168062e6eb363
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Citations in the corpus
- Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines (2015, background): “A small RCT of supervised exercise in major depression in adults found that 12 weeks of high-intensity exercise was significantly more effective than low-intensity exercise and stretching exercise in mild severity depression (Dunn et al., 2005), and that 10 days of endurance training was more effect”
- Evidence for prescribing exercise as therapy in chronic disease (2006, background): “A recent study investigated the effect of different exercise regimens performed in a supervised laboratory setting in adults (n5 80) aged 20–45 years diagnosed with mild to moderate major depressive disorder (Dunn et al., 2005).”
- Depression as a disease of modernity: explanations for increasing prevalence (2012, background): “Exercise appears to reduce depressive symptoms (Dunn and Dishman, 1991) and does so in a dose-dependent manner (Dunn et al., 2005).”
- Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder (2007, background): “3 History of or current smoking, n (%) 28 (55) 21 (43) 19 (41) 22 (47) 90 (45) Current smoking, n (%) 8 (15) 7 (14) 9 (19) 8 (17) 32 (16) Alcohol: 3 alcoholic drinks per week, n (%) 4 (8) 3 (6) 3 (6) 5 (10) 15 (7)”
- Exercise for the Treatment of Depression and Anxiety (2011, background): “Subsequently, physical activity has been shown to be associated with decreased symptoms of depression and anxiety in numerous studies [22-25].”
- Physical activity, exercise, depression and anxiety disorders (2009, background): “1993) and in patients with major depression (Blumenthal et al. 1999; Dunn et al. 2005; Singh et al. 2005; Martinsen et al. 1985; Klein et al. 1985; Veale et al. 1992; McNeil et al. 1991; Singh et al. 2001; Dimeo et al. 2001).”
- A systematic review of the psychological and social benefits of participation in sport for children and adolescents: informing development of a conceptual model of health through sport (2013, background): “Conversely, there is research indicating that children who are active through sport are more likely to be physically active in adulthood than those who do not participate in childhood sport [8,9].”