Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

By G. Hayhurst, Ying-Hue Lee, G. Lambert, J. Ward, F. Gonzalez. Molecular and Cellular Biology, 2001

1,100 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes (2009, background): “Liver-specific deletion of the Hnf4a gene (Hayhurst et al., 2001) has a sex-dependent impact on gene expression in liver, with 1000 fewer genes responding to the loss of HNF4 in female compared with male mice (Holloway et al., 2008).”
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits (2009, background): “HNF4� is an essential hepatic transcriptional activator that has been associated with metabolic pathways (8) and has been shown to activate LIPC, an important enzyme in lipid metabolism (9).”
Common variants at 30 loci contribute to polygenic dyslipidemia (2008, background): “Although mice lacking either Hnf4a or Hnf1a have altered plasma cholesterol level”
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006, background): “The inclusion of the hepatocyte nuclear factor-4 orphan receptors (HNF4a and g) reflects the role of these NRs in gastro/enterohepatic developmental programs, carbohydrate metabolism, and insulin action (Chen et al., 1994; Hayhurst et al., 2001; Shih and Stoffel, 2002).”
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. (2003, methodology): “This transgene was used in an earlier study to create an HNF4α liver-null mouse (23).”