An evolutionarily conserved mechanism for controlling the efficiency of protein translation.

By T. Tuller, A. Carmi, Kalin Vestsigian, Sivan Navon, Yuval Dorfan, J. Zaborske, T. Pan, Orna Dahan, Itay Furman, Yitzhak Pilpel. Cell, 2010

875 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6933240c368924f66c9d35e3f3027bad4afb834d

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Citations in the corpus

Understanding the contribution of synonymous mutations to human disease (2011, methodology): “For example, such an approach was used to determine whether there are conserved patterns in the distribution of rare and frequent codons across individual mRNAs and in the transcriptom”
Codon Bias as a Means to Fine-Tune Gene Expression (2015, background): “Variable local translation rates can regulate the even distribution of translating ribosomes on the mRNA (Tuller et al., 2010), tune the protein co-translational folding process (Zhang et al., 2009), and facilitate protein translocation across membranes (Pechmann et al., 2014).”
Codon optimality is a major determinant of mRNA stability (2015, background): “Critically, optimal codons are postulated to be decoded faster and more accurately by the ribosome than non-optimal codons (Akashi, 1994; Drummond and Wilke, 2008), which are hypothesized to slow translation elongation (Novoa and Ribas de Pouplana, 2012; Tuller et al., 2010).”
Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction (2013, positive): “…conditions will allow for a deeper understanding of nutrient limitation-dependent effective catalytic rates, and new data sets (Li et al, 2012) and models (Tuller et al, 2010) on the processes of gene expression can help to refine model parameters and determine their genome-scale effects.”
PaxDb, a Database of Protein Abundance Averages Across All Three Domains of Life (2012, background): “sequence (22), its codon usage (23), translation regime (24),”
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity of Mammalian Proteomes (2011, background): “An earlier analysis had suggested that the excess ribosomes extending over 100 codons at the beginning of Saccharomyces cerevisiae ORFs reflected a broadly conserved ‘‘ramping’’ strategy that minimized ribosome stacking and collisions later in the messages (Tuller et al., 2010).”