A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

By Shawn M. Douglas, I. Bachelet, George M. Church. Science, 2012

1,931 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6917baa1daad7bf5cea8867fac7195a97153e3c6

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In Biomedical Engineering

In Molecular Biology

Citations in the corpus

Squeezed Thermal Reservoirs as a Resource for a Nanomechanical Engine beyond the Carnot Limit (2017, background): “A major open question remains whether highly miniaturized heat engines, such as the one reported here, will be able to use the extracted work to accomplish mesoscopic tasks as transporting particles [31] or manipulating biological matter [32].”
The delivery of therapeutic oligonucleotides (2016, background): “When the aptamers engaged their cognate cellular ligands the box opened to release entrapped contents (327).”
Universal computing by DNA origami robots in a living animal (2014, neutral): “15) as previously described 19 .”
The Beauty and Utility of DNA Origami (2017, background): “From Douglas et al.110 Reprinted with permission from AAAS.”
Large-scale de novo DNA synthesis: technologies and applications (2014, methodology): “The emergence of DNA origami 123 and single-stranded tiles to form complex 2D and 3D shapes [124] [125] [126] has been used by researchers to tackle problems from materials 127 to therapeutics 128 .”
Programmable materials and the nature of the DNA bond (2015, background): “cluding a box with a sequence-specific opening lid (53) and a barrel-shaped structure that can carrymolecular payloads and release thembased on intracellular logic-gated aptamer binding events (54).”
Biomolecular computing systems: principles, progress and potential (2012, background): “…carrying molecular cargo was programmed to bind to cells and to open and release the cargo only when the cells expressed two surface markers simultaneously 112 , bringing computing back into the picture and pointing towards a novel logic-driven approach to selective drug delivery in vivo .”
Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles’ Physicochemical Properties on Responses in Biological Systems (2023, background): “For instance, researchers at the Wyss Institute of Harvard University developed a “nano-robot” that can specifically target cancer cells to deliver anticancer drugs [28].”