A Novel Wound Dressing Based on Ag/Graphene Polymer Hydrogel: Effectively Kill Bacteria and Accelerate Wound Healing
By Zengjie Fan, B. Liu, Jinqing Wang, Song Zhang, Q. Lin, Peiwei Gong, Limin Ma, Shengrong Yang. 2014
736 citations recorded by the source corpus.
Avoiding wound infection and retaining an appropriate level of moisture around woundz are major challenges in wound care management. Therefore, designing hydrogels with desired antibacterial performance and good water‐maintaining ability is of particular significance to promote the development of wound dressing. Thus a series of hydrogels are prepared by crosslinking of Ag/graphene composites with acrylic acid and N,N′‐methylene bisacrylamide at different mass ratios. The antibacterial performance and accelerated wound‐healing ability of hydrogel are systematically evaluated with the aim of attaining a novel and effective wound dressing. The as‐prepared hydrogel with the optimal Ag to graphene mass ratio of 5:1 (Ag5G1) exhibits stronger antibacterial abilities than other hydrogels. Meanwhile, Ag5G1 hydrogel exhibits excellent biocompatibility, high swelling ratio, and good extensibility. More importantly, in vivo experiments indicate that Ag5G1 hydrogel can significantly accelerate the healing rate of artificial wounds in rats, and histological examination reveals that it helps to successfully reconstruct intact and thickened epidermis during 15 day of healing of impaired wounds. In one word, the present approach can shed new light on designing of antibacterial material like Ag/graphene composite hydrogel with promising applications in wound dressing.
Subfields: Biomaterials, Biomedical Engineering, Rehabilitation
View Paper: https://www.semanticscholar.org/paper/6915169a1ceb094759b414695afa5bd4b485eb12
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Citations in the corpus
- A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings (2017, methodology): “[94], using ammonium persulphate as a thermal initiator.”
- Drug Delivery Systems and Materials for Wound Healing Applications (2018, neutral): “There are examples of carbon-based systems used in treatment of chronic wounds [184].”