Gene conversion: mechanisms, evolution and human disease

By Jian-Min Chen, David N. Cooper, N. Chuzhanova, C. Férec, George P. Patrinos. Nature reviews genetics, 2007

645 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/68d3dddbfcaa2fcbd9f354470ca26400e0c06683

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

In Plant Science

Citations in the corpus

Biased gene conversion and the evolution of mammalian genomic landscapes. (2009, background): “The limited data presently available indicate that gene-conversion tracts are usually shorter than in yeast, of the order of 200 bp to 1 kb in length (26), and that noncrossovers lead to shorter conversion tracts than do crossovers (68).”
Efficient ancestry and mutation simulation with msprime 1.0 (2021, background): “Gene conversion is a form of recombination that results in the transfer of a short segment of genetic material, for example be-tween homologous chromosomes (Chen et al. 2007).”
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery (2007, background): “The homologous recombination pathway, which evolved to resolve stalled DNA replication forks, repair DNA double-strand (ds) breaks and foster genetic recombinatio”
Whole Genome Sequencing in Autism Identifies Hotspots for De Novo Germline Mutation (2012, neutral): “Multiple mutational mechanisms could explain these findings, including compound mutation (Schrider et al., 2011) or gene conversion (Chen et al., 2007).”
Identifying a Carotenoid Cleavage Dioxygenase (ccd4) Gene Controlling Yellow/White Fruit Flesh Color of Peach (2013, background): “On the other hand, somatic gene conversion events occurring between alleles that reside on homologous chromosomes have been reported (Chen et al. 2007); such an event could originate a W allele starting from y, using y as donor for the central part of the gene.”
Human and chimpanzee Luteinizing hormone/ Chorionic Gonadotropin beta (LHB/CGB) gene clusters: diversity and divergence of young duplicated genes (2009, background): “In addition to affecting the evolution of gene families and genome variation patterns, gene conversion events have been implicated as the molecular cause of an increasing number of human diseases (reviewed in (Chen et al. 2007)).”
Single-copy insertion of transgenes in Caenorhabditis elegans (2008, background): “The presence of errors suggests that insertion proceeds by synthesis-dependent strand annealin”
Adaptive introgression in animals: examples and comparison to new mutation and standing variation as sources of adaptive variation (2013, background): “If gene conversion (Chen et al. 2007; Klitz et al. 2012), which can generate new variants by trans-”
The linkage disequilibrium and the selection of genetic markers for association studies in European populations (2007, background): “In the case of gene conversion, a short stretch of one copy of chromosome is transferred to another during meiosis – the effect is the same as that of two very close recombinations (Ardlie et al. 2002; Chen et al. 2007).”
A new theory of MHC evolution: beyond selection on the immune genes (2009, background): “Possibly, gene conversion could reduce genetic loads if a short track of sequence is converted by a donor sequence without mutations, or if interallelic gene conversion occurs between paralogous genes (Ohta 1989; Chen et al. 2007).”