Roles of intestinal epithelial cells in the maintenance of gut homeostasis
By Ryu Okumura, K. Takeda. Experimental &Molecular Medicine, 2017
612 citations recorded by the source corpus.
The intestine is a unique organ inhabited by a tremendous number of microorganisms. Intestinal epithelial cells greatly contribute to the maintenance of the symbiotic relationship between gut microbiota and the host by constructing mucosal barriers, secreting various immunological mediators and delivering bacterial antigens. Mucosal barriers, including physical barriers and chemical barriers, spatially segregate gut microbiota and the host immune system to avoid unnecessary immune responses to gut microbes, leading to the intestinal inflammation. In addition, various immunological mediators, including cytokines and chemokines, secreted from intestinal epithelial cells stimulated by gut microbiota modulate host immune responses, maintaining a well-balanced relationship between gut microbes and the host immune system. Therefore, impairment of the innate immune functions of intestinal epithelial cells is associated with intestinal inflammation.
Subfields: Gastroenterology, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6877c6c1b36f702c692eca3cfb8aaa64c64b3d45
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Citations in the corpus
- The Potential Use of Probiotics to Improve Animal Health, Efficiency, and Meat Quality: A Review (2020, background): “The second is to deliver signals to immune cells in response to metabolites produced by the gut microbiome, which, in turn, invokes an immune response [31].”